自然感染之貓傳染性腹膜炎臨床與實驗室檢查之研究

外文標題: 
Clinical and laboratory findings of feline infectious peritonitis in naturally infected cats
校院系所: 
臺灣大學 臨床動物醫學研究所
指導教授: 
蘇璧伶
出版年份: 
2008年
主題類別: 
摘要: 

本研究收集51隻經由屍解病理學確診的自然感染貓傳染性腹膜炎(feline infectious peritonitis,簡稱FIP)發病貓的基本資料及一系列的各項檢驗結果進行研究,找尋可供臨床上病程分級之參考。30隻貓(30/51, 58.8%)為濕式FIP,12隻貓(12/51, 23.5%)為乾式FIP,另外9隻貓(9/51, 17.6%)為混合式FIP。年齡分布由3個月大至7歲,一歲以下小貓佔74.5% (38/51)為最大量。發病公貓與母貓比例為49% (25/51)與51% (26/51),無顯著差異。初次就診常見食慾下降(55.6~75%)、發燒(50~77.8%)和精神沉鬱(33.3~60%)等臨床症狀。使用 RT-PCR檢測貓冠狀病毒時,胸水和腹水有較高檢出率,分別為100% (9/9)和94.4% (17/18),直腸拭子於乾式和濕式FIP也有較高檢出率,為66.7% (12/18)和60% (18/30)。隨病程進展臨床病理學會出現貧血、淋巴球減少、高膽紅素血症、低白蛋白血症、高蛋白血症、ALT及AST升高、低血鈉及低血鉀等異常。無論乾濕式FIP貓比較其初次就診與死前0-3天之血檢,可發現血容比由26.5±7.0%降至17.0±4.6%、膽紅素由0.7±1.0 mg/dL升為2.5±1.3 mg/dL、白蛋白由2.5±0.3 g/dL降至2.2±0.4 g/dL,皆有極顯著差異(p

外文摘要: 

Fifty-one naturally infected feline infectious peritonitis (FIP) diseased cats were enrolled in this study for staging of the course of FIP disease. Effusive FIP was found in 30/51 cats (58.8%), whereas non-effusive FIP was diagnosed in 12/51 cats (23.5%), and nine cats (9/51, 17.6%) were mixed type. The age ranged from 3 month-old to 7 year-old. Most of them were less than 1-year-old (38/51, 74.5%). Twenty-five of 51 (49%) cats with FIP were male while 26 (51%) were female. There was no gender prevalence. Anorexia (55.6~75%), fever (50~77.8%), and depression (33.3~60%) were the major clinical signs at presenting. Higher detection rate of coronavirus by RT-PCR was found in pleural effusion (9/9, 100%), ascites (17/18, 94.4%), and rectal swabs (66.7% in non-effusive FIP, 60% in effusive FIP). The clinicopathological changes include anemia, lymphopenia, hyperbilirubinemia, hypoalbuminemia, hyperproteinemia, elevation of ALT and AST, hyponatremia, and hypokalemia. Highly significant (p